Everything that begins must eventually end. This episode of beginnings and endings walks us both backwards and forwards as we take our final stroll down Wisteria Lane.
Alexander is convinced that a lightning strike on St. Peter's Basilica during mass was a sign of God's disapproval; Cesare tries to prove his worth as a military commander; the Pope pressures the reluctant Lucrezia to enter another political marriage.
When Stan catches Steve playing imaginary games with his toys, he decides to take his son down to Mexico to help him become a man. But the trip takes a turn for the worse when Stan and Steve are kidnapped by a drug cartel, and it’s up to Steve to break himself and Stan out of captivity.
When city hall threatens to close Peter's business, he joins the Tea Party and campaigns to shut down the government.
Don attempts to regain his creative spark, but undermines a member of his staff while doing so. Roger pursues some new clients, and in the process, hurts Jane. Betty displays her pettiness when she reveals a distressing secret to Sally.
Marlene wants see a concert but every time she leaves the zoo she becomes a monster!
When Harry's client is acquitted of raping and murdering his ex-girlfriend, the victim's father and brother take the courtroom hostage. Meanwhile, a friend of Cassie's needs help after being in a car accident.
Ma takes up residence in the Penguins Lair. She smothers the penguins with love and they devolve into a bunch of softies, opening the door for Hans to take advantage.
Dan and Amy try to figure out if an Asian-American war hero-cum-governor could be a political threat to Selina. Meanwhile, Selina and Mike prep for her "Meet the Press" interview; and Gary and Amy make a startling discovery about Selina's romantic life.
Jaime meets a distant relative; Dany receives an invitation; Theon leads a search party; Jon loses his way in the wilderness.
Cleveland's plan to bring in an actress to play Donna's long-lost mother backfires on him, but actually brings Donna's real mom out of hiding.
Anthony attends the grand opening of his new salon; a secret turns Christy against Gayle; Olivia makes a workout video.
It is bad enough Spider-Man catches a cold, but things drop from bad to worse when a new Spider-Man dressed in black attempts to replace him. Are his friends right and is his jealousy is getting the best of him, or is the new Spider-Man Venom's latest victim?
Adam and Jamie take aim at a ricochet myth from the TV show Burn Notice while Kari, Tory and Grant test the Hollywood myth that if you jump when running away from an explosion, you can surf the shockwave.
Holder disappears and a desperate Sarah goes looking for him; Stan decides to take matters into his own hands; and Richmond returns to City Hall.
Amy convinces Mary Lou Wentz to throw her a baby shower, but the event turns bad when Charlie blurts out all the horrible things Amy said about her baby shower guests.
The guys pull pranks and go on vacation to celebrate the release of their album, but Nathan senses that something is not right with their latest release. Meanwhile, Skwisgaar and Toki plot revenge on Murderface for his pranks.